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Novel boronic acid derivatives of bis(indolyl) methane as anti-MRSA agents |
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| Authors: | Santi M Mandal Rupa Pegu William F Porto Octavio L Franco Sanjay Pratihar |
| Institution: | 1. Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India;2. Department of Chemical Sciences, Tezpur University, Napaam 784028, Assam, India;3. Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília-DF, Brazil;4. 4S-Inova Biotech, Pós-graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil |
| Abstract: | Towards the search for a new generation of antibiotics to control methicillin-resistant Staphylococcus aureus (MRSA), the design and synthesis of various bis indolyl methane (BIM) derivatives based on their different electron donor and acceptor properties of the substituents have been made, in which boronic acid derivatives of BIM are found to be active against MRSA. The observed evidence with the lead compound reveals their strong anti-MRSA activity, which paves the way of design and further development of a new generation antibiotics. |
| Keywords: | Bis(indolyl) methane MRSA New generation antibiotics Bacterial cell wall Leucyl-tRNA synthetase |
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