线粒体质量控制与米色脂肪之间的关系

近年来,肥胖患病率不断上升,肥胖已成为全球性公共卫生问题.肥胖能够增加高血压、冠心病等心血管疾病的发病风险,防治肥胖已经成为亟待解决的社会问题.米色脂肪是一种产热型脂肪细胞,可在受到寒冷、药物、运动等外界刺激下由白色脂肪细胞转化而来,但其形态和功能却与白色脂肪细胞不同,而与棕色脂肪细胞类似,即米色脂肪同样含有丰富的线粒...

The Relationship Between Mitochondrial Quality Control and Beige Adipocytes

The prevalence of obesity has been rising in recent years. Obesity has become one of the global public health problems, which can increase the risk of hypertension, coronary heart disease and other cardiovascular diseases, and prevention and treatment of obesity has become an urgent social problem to be solved. Beige adipocytes are new kind of heat-producing adipocytes, which can be transformed by white adipocytes stimulated by chronic cold exposure, some medicine and exercise. The morphology and function of beige adipocytes are different from white adipocytes, but are similar to brown adipocytes. Beige adipocytes have abundant mitochondria and can produce heat to consumer energy, which are new target for the prevention and treatment of obesity. Mitochondria is the main part of energy metabolism in eukaryotic cells, which can provide energy to the body. Mitochondrial quality control regulates mitochondrial quantity and quality in beige adipocytes, which can affect the conversion and thermogenesis of beige adipocytes. Mitochondrial quality control is regulated by several coordinated mechanisms including mitochondrial biogenesis, mitophagy and fission/fusion. The mitochondrial biogenesis and mitophagy can regulate mitochondrial renewal and degradation, and the mitochondrial fusion/division is responsible for mitochondrial repairing. Some studies have found that the change of mitochondrial quantity, morphology and function can affect the beige adipocytes formation, beige adipocytes maintenance and thermogenesis. However, the relationship between mitochondrial quality control and beige adipocytes remains unclear. In this review, we discuss the effect of mitochondrial biogenesis，mitophagy and mitochondrial fission/fusion on beige adipocytes, and illustrate the relationship between mitochondrial quality control and beige adipocytes, which may provide new insights into the prevention and treatment of obesity.