Determination of DNA sequence changes induced by ethyl methanesulfonate in human cells, using a shuttle vector system. |
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Authors: | J S Lebkowski J H Miller M P Calos |
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Abstract: | The DNA sequence changes for 54 mutations induced in human cells by the alkylating agent ethyl methanesulfonate are reported. The mutations were obtained by using a shuttle vector system with the bacterial lacI gene as the target. Of the 54 mutations obtained, 53 were G:C to A:T transitions. |
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