磁共振波谱分析与帕金森病患者Hoehn&Yahr分级的相关性研究

目的:探讨磁共振波谱分析(MRS)与帕金森病(PD)HoehnYahr分级之间的相关性。方法:选择2016年9月-2017年8月我院收治的60例PD患者为研究对象,根据HoehnYahr分级将患者分为早期PD组32例、中期PD组18例、晚期PD组10例,并选择同时期在门诊进行健康体检的20例志愿者作为对照组。对各组研究对象的双侧基底节、双侧额叶、双侧丘脑区进行MRS,并分析PD患者HoehnYahr分级与MRS的关系。结果:晚期PD组双侧基底节、双侧额叶、双侧丘脑区NAA/Cr、NAA/Cho、Cho/Cr比值均低于中期PD组、早期PD组、对照组,且中期PD组低于早期PD组、对照组,早期PD组低于对照组,差异有统计学意义(P0.05)。通过Spearman相关性分析显示,MRS检测出PD患者NAA/Cr、NAA/Cho、Cho/Cr比值与HoehnYahr分级间呈负相关性(P0.05)。结论:MRS与PD患者的HoehnYahr分级具有负相关性,并且可通过MRS预测患者疾病的严重程度,以对其进行相应的治疗以及预后评估。

Correlation Between Magnetic Resonance Spectroscopy and Hoehn & Yahr Classification in Patients with Parkinson's Disease

ABSTRACT Objective: To investigate the correlation between magnetic resonance spectroscopy (MRS) and Hoehn & Yahr classifi- cation of Parkinson''s disease (PD). Methods: A total of 60 PD patients, who were admitted to Zhengzhou Central Hospital from Septem- ber 2016 to August 2017, were selected as the research subjects and were divided into early PD group(n=32), middle PD group(n=18),and late PD group (n=10) according to the Hoehn&Yahr classification; 20 volunteers at the same time in the outpatient clinic were selected as control group. MRS was performed on bilateral basal ganglia, bilateral frontal lobes and bilateral thalamus area in each group, and the relationship between Hoehn&Yahr and MRS among the PD patients was analyzed. Results: The ratios of NAA/Cr, NAA/Cho, Cho/Cr in bilateral basal ganglia, bilateral frontal lobes and bilateral thalamus in the late PD group were significantly lower than those in the Medi- um PD group, the early PD group and the control group; the indexes of middle PD group were lower than those of the early PD group and the control group, and the indexes of early PD group were lower than those of the control group, the differences were statistically signifi- cant (P<0.05). Spearman correlation analysis showed that MRS detected the negative correlation between NAA/Cr, NAA/Cho, Cho/Cr ratio and Hoehn&Yahr classification in PD patients (P<0.05). Conclusion: MRS has a negative correlation with Hoehn & Yahr classifica- tion of PD, and the severity of the disease can be predicted by MRS, which can be given corresponding treatment and prognosis assess- ment.