PIG11、Caspase-3蛋白在胃癌中的表达及临床意义

目的:探讨PIG11、Caspase-3蛋白在胃癌中的表达及临床意义。方法:采用免疫组织化学SP法检测80例胃癌组织、36例正常胃黏膜组织、30例肠上皮化生组织及31例异型增生组织中PIG11、Caspase-3蛋白的表达水平,并分析其表达与胃癌临床病理特征的关系及两者之间的相关性。结果:胃癌组织中PIG11、Caspase-3蛋白的阳性表达率均显著低于正常胃黏膜、肠上皮化生及异型增生组织(P0.01);PIG11、Caspase-3蛋白表达水平与胃癌的分化程度、临床分期、有无淋巴结转移及远处转移密切相关(P0.05),但与患者的年龄、性别及肿瘤的浸润深度无关(P0.05);PIG11、Caspase-3蛋白在胃癌组织中的表达呈正相关(r=0.859,P0.01)。结论:PIG11、Caspase-3蛋白在胃癌中明显表达下调,且与胃癌的分化程度、临床分期、有无淋巴结转移及远处转移密切相关,可能作为胃癌预后评估的参考指标。PIG11表达下调可能通过抑制Caspase-3的表达促进胃癌的发生和发展。

Expressions and Clinicopathological Significances of PIG11 and Caspase-3 Protein in the Gastric Carcinoma

ABSTRACT Objective: To investigate the expressions and and clinicopathological significances of PIG11and Caspase-3 protein in gastric cancer. Methods: Immunohistochemical staining was applied to detect the expressions of PIG11 and Caspase-3 protein in gastric cancer tissues (80 cases), normal tissues (36 cases), intestinal metaplasia tissues (30 cases) and dysplasia tissues (31 cases). The relationship between protein expression of PIG11and Caspase-3 and clinicopathological features of gastric carcinoma were analyzed. Results: The positive expression rates of PIG11 and Caspase-3 protein were significantly lower in gastric cancer tissue than those in the normal gastric tissue, intestinal metaplasia and dysplasia tissues (P<0.01 respectively). The positive expression rates of PIG11 and Caspase-3 were correlated with the differentiation degree, clinical stage, lymph node metastasis and distant metastasis of gastric cancer(P<0.05 respectively). The expression of Caspase-3 was positively correlated with PIG11 expression (r=0.859, P<0.01). Conclusion: The expressions of PIG11 and Caspase-3 protein were significantly reduced in gastric cancer and were closely related with the differentiation degree, clinical stage, lymph node metastasis and distant metastasis of gastric cancer, which may be used as biomarkers of clinical prognosis of gastric cancer. The down-regulation of PIG11 expression maybe involved in the tumorigenesis and development in gastric cancer by inhibiting the expression of Caspase-3.