泛福舒胶囊联合参麦注射液治疗儿童支气管哮喘的疗效及对血清IL-4、hs-CRP、Ang-2的影响

目的:研究泛福舒胶囊联合参麦注射液治疗儿童支气管哮喘的疗效及对血清IL-4(Interleukin-4)、hs-CRP(Hypersensitive c-reactive protein)、Ang-2(Angiotensin-2)的影响。方法:选择2015年3月至2017年3月在我院接受治疗的支气管哮喘患儿120例,根据治疗方案不同分为观察组和对照组,对照组使用常规治疗,观察组在对照组的基础给予静脉滴注参麦注射液联合泛福舒胶囊治疗,两组患者均治疗3个疗程。治疗后,观察和比较两组患者的临床疗效,治疗前后PEF(peak expiratory flow)、FEV1(forced expiratory volume)水平、T淋巴细胞亚群水平、血清IL-4、hs-CRP、Ang-2水平的变化。结果:治疗后,观察组总有效率(91.7%)明显高于对照组(73.3%)(P0.05)。与治疗前相比,两组患者治疗后血清IL-4、hs-CRP、Ang-2水平均明显降低,PEF、FEV1水平明显升高(P0.05);与对照组相比,观察组血清IL-4、hs-CRP、Ang-2水平明显较低,PEF、FEV1水平明显较高(P0.05)。治疗后,与对照组比较,观察组CD3~+、CD4~+水平显著升高,CD8~+水平及CD4~+/CD8~+比值显著降低(P0.05)。结论:泛福舒胶囊联合参麦注射液治疗儿童支气管哮喘可有效提高其临床疗效,改善其肺功能,可能与其显著降低患儿血清IL-4、hs-CRP、Ang-2水平有关。

Clinical Efficacy of Bronchovaxom Capsule Unite Shenmai Injection in the Treatment of Children with Bronchial Asthma and Its Effect on the Serum Levels of IL-4, hs-CRP, Ang-2

ABSTRACT Objective: To study the clinical efficacy of bronchovaxom capsule unite Shenmai Injection in the treatment of children with bronchial asthma and its effect on the serum levels of IL-4, hs-CRP, Ang-2. Methods: 120 cases of children with bronchial asthma who were treated from March 2015 to March 2015 were selected as research objects and divided into the observation group and the control group according to different treatment. The control group was given conventional treatment, while the observation group was treated with bronchovaxom capsule combined with Shenmai injection, both groups of children were treated for three courses. After treatment, the clinical efficacy, changes of PEF, FEV1, T lymphocytic subgroup, serum IL-4, hs-CRP, and Ang-2 before and after treatment were compared between two groups. Results: After treatment, the total effective rate of observation group (91.7%) was significantly higher than that of the control group (73.3%) (P<0.05), the serum IL-4, hs-CRP, and Ang-2 levels of both groups were significantly decreased than those before treatment, while the PEF and FEV1 were obviously elevated(P<0.05). Compared with the control group, the serum IL-4, hs-CRP, and Ang-2 levels were significantly lower in the observation group, and the levels of PEF and FEV1 were significantly higher(P<0.05). After treatment, the CD3⁺, CD4⁺ levels of observation group were significantly higher than those of the control group, whereas the CD8⁺ level and CD4⁺/ CD8⁺ ratio were significantly decreased(P<0.05). Conclusion: Bronchovaxom capsule combined with shenmai injection could effectively enhance the clinical curative effect, improve the pulmonary function in the treatment of children with bronchial asthma, which might be related to the reduce of serum IL - 4, hs CRP, Ang - 2 levels.