脂肪组织氧化应激与运动干预

脂肪组织在调控代谢稳态和运动适应中扮演着重要的角色。肥胖引起的脂肪组织氧化应激是2型糖尿病与代谢综合征等的重要病理特征，是促进脂肪组织炎症和胰岛素抵抗的重要机制。氧化应激可以引起脂肪细胞趋化因子表达，募集炎症细胞浸润脂肪组织，炎症细胞分泌大量的炎症因子,并促进了局部和系统的胰岛素抵抗与慢性炎症。运动对肥胖相关的慢性代谢病的有效干预与运动的抗氧化效应相关。本文总结了氧化应激在脂肪组织炎症和胰岛素抵抗中的作用，以及运动对脂肪组织氧化应激的调控。

Oxidative Stress of Adipose Tissues and Exercise Intervention

Adipose tissues play important roles in metabolic homeostasis and exercise adaptation. Obesity-induced oxidative stress in adipose tissues is one of the main pathological features of type 2 diabetes, metabolic syndrome, as well as an important risk factor inflammation and insulin resistance in adipose tissues. Oxidative stress induces the expression of chemokines, which recruit monocytes/macrophages into adipose tissues. Pro-inflammatory cytokines secreted by pro-inflammatory immune cells contribute a lot to local and systemic insulin resistance and inflammation. The positive effect of exercise on obesity-related chronic metabolic diseases is closely associated with anti-oxidative effects induced by exercise. This paper reviews recent studies about the role of oxidative stress in adipose tissue inflammation, insulin resistance as well as the regulation of oxidative stress in adipose tissues by exercise.