腹腔镜肝癌切除术对肝细胞癌中的治疗效果及对血清AFP、sEC、HGF、ICAM-1的影响

目的:研究腹腔镜肝癌切除术对肝细胞癌中的治疗效果及对血清AFP、sEC、HGF、ICAM-1的影响。方法:选择2012年3月至2017年3月在我院接受治疗的肝细胞癌患者196例,根据治疗方案不同分为观察组和对照组,对照组给予开腹切除术治疗,观察组给予腹腔镜切除术治疗。观察并比较两组手术前后血清甲胎蛋白(AFP)、sEC、人类生长因子(HGF)、细胞间黏附分子-1(ICAM-1)及总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)及白蛋白(Alb)水平,术中出血量、术后绝对卧床时间、住院时间以及并发症发生率。结果:术后,观察组血清AFP、sEC、HGF、ICAM-1水平均明显低于对照组(P0.05);观察组TBIL、DBIL、ALT水平均显著低于对照组,Alb则显著高于对照组(P0.05);观察组术中出血量、绝对卧床时间以及住院时间均明显低于对照组(P0.05);且观察组术后并发症发生率明显低于对照组(P0.05)。结论:使用腹腔镜肝癌切除术治疗肝细胞癌,可降低患者血清AFP、sEC、HGF、ICAM-1水平从而提高其治疗效果,且术后并发症发生率较低。

Application of Laparoscopic Hepatectomy in Hepatocellular Carcinoma and Its Effects on Level of AFP, sEC, HGF, ICAM-1

ABSTRACT Objective: To study application of laparoscopic hepatectomy in hepatocellular carcinoma and its effects on levels of AFP, sEC, HGF and ICAM-1. Methods: 196 patients of hepatocellular carcinoma who received therapy from March 2012 to March 2012 in our hospital were selected as research objects, according to the different treatment is divided into observation group and control group. The control group was treated with open abdominal resection, while the observation group was treated with laparoscopic hepatectomy. Then AFP, sEC, HGF, ICAM-1 levels, liver function (TBIL, DBIL, ALT, Alb), Intraoperative blood loss, absolute bed time after surgery, length of stay, postoperative complications were compared. Results: After the operation, the serum AFP, sEC, HGF, ICAM-1 levels in observation group was less than the control (P < 0.05); TBIL, DBIL and ALT levels in observation group was less than the control, while Alb in observation group was higher than the control (P < 0.05); The blood volume, absolute bed time and hospitalization time in observation group was less than the control (P < 0.05); The postoperative complications in observation group was less than the control (P < 0.05). Conclusion: Using laparoscopic hepatocellular carcinoma treatment of hepatocellular carcinoma, it can reduce serum AFP, sEC, HGF, ICAM-1 level, and improve its therapeutic effect, and the incidence of complications is low.