肺癌患者外周血淋巴细胞亚群水平的表达及临床意义

目的:探讨肺癌患者外周血淋巴细胞亚群水平的表达及临床意义。方法:选择2016年3月~2017年3月期间我院收治的88例肺癌患者作为研究组,选择同期于我院进行健康体检的88例受检者作为对照组。两组研究对象均通过流式细胞仪检测外周血T淋巴细胞亚群水平。观察对比两组研究对象外周血T淋巴细胞亚群的表达水平,以及研究组不同临床病理特征患者外周血T淋巴细胞亚群的表达水平。结果:研究组CD4~+/CD8~+、CD4~+、CD3~+表达水平均低于对照组,CD8~+表达水平高于对照组,差异具有统计学意义(P0.05)。研究组Ⅲ期与Ⅳ期患者CD4~+/CD8~+、CD4~+、CD3~+表达水平均低于Ⅰ期与Ⅱ期,Ⅲ期与Ⅳ期患者CD8~+表达水平高于Ⅰ期与Ⅱ期(P0.05);小细胞肺癌患者CD4~+/CD8~+、CD4~+、CD3~+表达水平均低于非小细胞肺癌患者,CD8~+表达水平高于非小细胞肺癌患者,差异具有统计学意义(P0.05)。不同性别、年龄、肿瘤分化程度肺癌患者CD4~+/CD8~+、CD8~+、CD4~+、CD3~+水平无统计学差异(P0.05)。结论:肺癌患者外周血淋巴细胞亚群水平的表达呈现异常状态,且表达水平与疾病的分期和病理分型有关。

Expression and Clinical Significance of Peripheral Blood Lymphocyte Subsets in Patients with Lung Cancer

ABSTRACT Objective: To investigate the expression and clinical significance of peripheral blood lymphocyte subsets in patients with lung cancer. Methods: A total of 88 patients with lung cancer,who were admitted to Second People''s Hospital of Yibin from March 2016 to March 2017, were chosen as study group; 88 subjects, who underwent physical examination in the hospital during the same period, were chosen as control group.The peripheral blood T lymphocyte subsets of the patients of the two groups were detected by flow cytometry. The expression levels of peripheral blood T lymphocyte subsets of the patients in the two groups were observed and compared, and the expression levels of peripheral blood T lymphocyte subsets of the patients with different clinicopathological characteristics in the study group were analyzed. Results: The expression levels of CD4⁺/CD8⁺, CD4⁺ and CD3⁺ in the study group were lower than those in the control group, the expression level of CD8⁺ was higher than that in the control group, the difference was statistically significant (P<0.05). The expression levels of CD4⁺/CD8⁺, CD4⁺ and CD3⁺ of the patients of the study group in stage III and IV were lower than those in stage I and II, and the expression level of CD8⁺ in stage III and IV was higher than that in stage I and II (P<0.05). The expression levels of CD4⁺/CD8⁺, CD4⁺ and CD3⁺ in the patients with small cell lung cancer were lower than those in the patients with non-small cell lung cancer, the expression level of CD8⁺ was higher than that in the patients with non-small cell lung cancer,the difference was statistically significant (P<0.05). There were no significant differences in the levels of CD4⁺/CD8⁺, CD4⁺ and CD3⁺ among the patients with different gender, age and tumor differentiation (P>0.05). Conclusion: The expression of peripheral blood lymphocyte subsets in the patients with lung cancer is abnormal,and the expression level is related to the stage and pathological type of lung cancer.