2型糖尿病患者APPL1、AFABP与胰岛素抵抗指数的相关性研究

目的:分析2型糖尿病(T2DM)患者磷酸酪氨酸衔接蛋白(APPL1)、脂肪细胞型脂肪酸结合蛋白(AFABP)与稳态模型评估胰岛素抵抗指数(HOMA-IR)的相关性。方法:选择2015年6月~2016年5月至我院就诊T2DM患者100例作为患病组,选取同期在我院健康体检者100例作为健康组,对研究对象进行指标如空腹血糖(FPG)、空腹血清胰岛素(FINS)、糖化血红蛋白(Hb A1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、APPL1、AFABP等检测,并根据公式计算HOMA-IR、及体重指数(BMI),分析APPL1、AFABP与各指标相关性。结果:患病组与健康组TC、HDL、LDL水平无明显差异(P0.05),患病组BMI、FPG、FINS、Hb A1c、TG、HOMA-IR、APPL1、AFABP与健康组比较明显较高(P0.05);APPL1与BMI、FINS、Hb A1c、HOMA-IR呈负相关性(P0.05),与FPG呈正相关性;AFABP与BMI、FPG、FINS、Hb A1c、HOMA-IR呈正相关性(P0.05)。结论:T2DM患者APPL1、AFABP较高,APPL1、AFABP与HOMA-IR呈直线相关性,表明APPL1、AFABP与T2DM患者胰岛素抵抗密切相关,该研究为APPL1、AFABP可以作为T2DM治疗的新靶点提供了理论依据。

Relationship of APPL1, AFABP and HOMA-IR in Type 2 Diabetes Mellitus Patients

ABSTRACT Objective: To analyze the relationship of Adaptor protein containing PH domain, PTB domain and leucine zipper motif 1 (APPL1), adipocyte fatty acid binding protein (AFABP) and homeostasis model assessment-Insulin resistance (HOMA-IR) in type 2 di- abetes mellitus (T2DM) patients. Methods: A total of 100 patients with T2DM, who were treated in Chongqing Southwest Hospital from June 2015 to May 2016, were chosen as patients group, and another 100 healthy people, who underwent physical examination in this hos- pital during the same period, were chosen as healthy group. Fasting blood glucose (FPG), fasting serum insulin (FINS), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), APPL1, AFABP of the subjects were detected. HOMA-IR and body mass index (BMI) were calculated according to the formula. The correlation between AP- PL1, AFABP and the other indexes were analyzed. Results: There was no significant difference in the levels of TC, HDL and LDL be- tween patients groups and healthy group (P>0.05). BMI, FPG, FINS, HbA1c, TG, HOMA-IR, APPL1, AFABP of the patients group were significantly higher than those of the healthy group(P<0.05). APPL1 was negatively associated with BMI, FINS, HbA1c and HOMA-IR (P<0.05), while positively associated with FPG(P<0.05). AFABP was positively associated with BMI, FPG, FINS, HbA1c and HOMA-IR (P<0.05). Conclusion: APPL1 and AFABP are higher in the patients with T2DM, and they are linearly related with HOMA-IR, which suggests that APPLl and AFABP may correlate with insulin resistance. The study provides a theoretical basis for APPL1 and AFABP used as a new target in the treatment of T2DM.