壳聚糖基温敏水凝胶的研究进展

壳聚糖是一种由甲壳素脱乙酰化得到的氨基多糖,具有生物相容性、低细胞毒性和可生物降解性等特点。壳聚糖/β-甘油磷酸钠溶液温敏水凝胶在组织工程、药物缓释等领域多有报道,其成胶性能取决于凝胶的组分和浓度。针对单纯壳聚糖水凝胶强度较低、降解较快、药物突释等缺陷,通常对壳聚糖进行改性或引入新材料共混,获得更符合实际需要的壳聚糖基温敏水凝胶。对近年来壳聚糖基水凝胶的研究进展进行综述,包括改性壳聚糖、共混体系等,概述了其在组织工程(软骨、血管、神经修复)、药物缓释(癌症药物缓释、糖尿病治疗)领域中研究和应用的新进展,以期为后续温敏水凝胶的进一步研究提供参考。

Research Progress of Chitosan Based Thermosensitive Hydrogels

Chitosan is a biocompatible, low-toxic and biodegradable amino polysaccharide obtained by deacetylation of chitin. The classic gelling system of chitosan/β-sodium glycerophosphate thermosensitive hydrogel has been widely reported in tissue engineering, drug controlled release and other fields. The gels properties depend on the composition and concentration of solutions. To improve the defects of weak mechanical property, rapid degradation and drug burst release, researchers modified chitosan or blended it with other materials, expecting to get better thermosensitive hydrogels based on chitosan. The recent advances in chitosan-based thermosensitive hydrogels including modified chitosan and blend hydrogel are summarized. Also summarizes the applications of those hydrogel in tissue engineering (repair of cartilage, blood vessels and nerve) and drug delivery release (controlled release of cancer drugs, diabetes treatment), in order to provide a reference for further research on the thermosensitive hydrogels.