高尿酸血症与肾脏疾病关系的研究进展

高尿酸血症(HUA)是血尿酸(UA)增高的一种疾病,也是常见的机体代谢紊乱,临床上大多数HUA患者无明显的症状。由于经济水平提高和生活方式的改变,其发病率有增高趋势,且男性高于女性。HUA多发于中老年人群,严重影响其生活质量,因此中老年人群HUA已经成为普遍关注的健康问题。近年来研究发现HUA是痛风的主要病因之一,并且血尿酸(UA)水平可导致肾功能减退。已有多项研究表明HUA与肾脏疾病的发生发展密切相关,HUA是Ig A肾病、糖尿病肾病、急性肾损伤等肾脏疾病的独立危险因素,本文主要从HUA的流行病学、危险因素、发病机制及其与肾脏疾病关系这几个方面展开综述。

Advances in the Relationship Between Hyperuricemia and Renal Diseases

ABSTRACT: Hyperuricemia is a disease of blood uric acid (UA) increased. It is also a common metabolic disorder in the body. Most patients with HUA have no obvious symptoms. Because of the improvement of the economic level and the change of lifestyle,hyperuricemia incidence has increased trend and male is higher than the female. HUA frequently occurs in middle-aged and elderly people, seriously affects their quality of life. Therefore, HUA has become universal concern health problem among the middle-aged and elderly people. In recent years, studies have found that HUA is one of the major causes of gout, and uric acid (UA) levels in the blood can lead to kidney failure. Many studies have found that HUA is closely related to the occurrence and development of kidney disease. HUA are independent risk factors of kidney disease, such as IgA nephropathy, diabetic nephropathy, acute kidney injury and so on. This article reviews the epidemiology, risk factors, pathogenesis and the relationship between HUA and renal diseases.