WT-1、Smac蛋白在上皮性卵巢癌中的表达和临床意义研究

目的:探讨WT-1和Smac蛋白在上皮性卵巢癌中的表达及其临床意义。方法:应用免疫组织化学染色方法检测40例正常卵巢组织,40例卵巢上皮性良性肿瘤组织,60例全面分期手术治疗的上皮性卵巢癌组织中WT-1、Smac蛋白的表达,并分析WT-1、Smac蛋白的表达与上皮性卵巢癌临床病理特征的相关性及二者之间的相关性。结果:WT-1蛋白在上皮性卵巢癌组织中的表达明显高于正常卵巢组织或卵巢上皮性良性肿瘤组织(P0.05);Smac蛋白在上皮性卵巢癌组织中表达明显低于正常卵巢组织或卵巢上皮性良性肿瘤组织(P0.05)。上皮性卵巢癌组织中WT-1、Smac蛋白的表达与肿瘤临床分期、组织分化程度、淋巴结有无转移均显著相关(P0.05)。且上皮性卵巢癌中WT-1、Smac蛋白的表达呈明显负相关性(r=-0.35,P0.05)。结论:WT-1蛋白高表达或Smac蛋白低表达可能在上皮性卵巢癌的发生、发展中发挥重要作用,检测WT-1、Smac蛋白的表达有助于上皮性卵巢癌恶性程度的判断和预后评估。

A Clinical Study on the WT-1 and Smac Protein Expressions in Epithelial Ovarian Cancer and the Clinical significances

ABSTRACT Objective: To investigate the expressions of WT-1 and Smac protein in epithelial ovarian cancer and their clinical significances. Methods: Immunohistochemistry was used to detect the expressions of WT-1 and Smac protein in 40 cases of normal ovarian tissues, 40 cases of epithelial ovarian benign tumor tissues and 60 cases of epithelial ovarian cancer tissues, the correlations of WT-1 expression with Smac expression and clinicopathological features of epithelial ovarian cancer were analyzed. Results: The expression of WT-1 protein in epithelial ovarian cancer tissues was significantly higher than that in the normal ovarian tissues or ovarian epithelial benign tumor tissues(P<0.05).The expression of Smac protein in epithelial ovarian cancer tissues was significantly lower than that in the normal ovarian tissues or ovaries epithelial benign tumor tissues(P<0.05). The expression of WT-1 and Smac protein in epithelial ovarian cancer was significantly correlated with the clinical stage, histological differentiation and lymph node metastasis(P<0.05). The expressions of WT-1 and Smac protein in epithelial ovarian cancer were negatively correlated(r=-0.35, P<0.05). Conclusion: High expression of WT-1 protein or low expression of Smac protein may play important roles in the occurrence and development of epithelial ovarian cancer, detection of WT-1 and Smac protein expressions may contribute to the prognostic prediction of epithelial ovarian cancer.