Nrf2及其药理性活化剂在糖尿病心血管并发症中的作用

糖尿病(DM)导致的心脑血管并发症是危害人类健康的重大疾病。氧化应激被认为是DM相关心血管并发症发生、发展的重要机制,但通过补充外源性抗氧化剂并未能使心血管疾病患者远期获益。核因子E2相关因子2(Nrf2)可增加内源性抗氧化酶的活性从而提高机体的抗氧化应激能力,可能是治疗糖尿病心血管并发症的一个重要靶点,提示靶向Nrf2药物的开发可能获得防治糖尿病相关血管并发症的新一代药物。本文就Nrf2在糖尿病相关心血管并发症发生、发展中的作用及其药理性活化剂对糖尿病(DM)相关心血管病变的治疗作用进行综述。

Nrf2 and Its Pharmacological Activators in Diabetes-related Cardiovascular Complication

ABSTRACT: Cardiovascular and cerebrovascular complications caused by diabetes is a major disease that endangers human health. Oxidative stress is thought to be an important mechanism for the occurrence and development of diabetes related cardiovascular complications. Supplementation of exogenous antioxidants does not benefit patients with cardiovascular disease. Nuclear factor E2 related factor 2 (Nrf2) could increase the activities of endogenous antioxidant enzymes thus enhance the antioxidant capacity of the body, which may be an important target for the treatment of diabetic cardiovascular complications. The present study suggests that the development of targeted Nrf2 drugs may lead to a new generation of drugs for the prevention and treatment of diabetic vascular complications. This article reviews the role of Nrf2 in the occurrence and development of cardiovascular complications associated with diabetes mellitus and the effects of pharmacological activators on the treatment of diabetic cardiovascular disease.