帕瑞昔布钠在术后镇痛中应用的研究进展

手术方式的不断完善和创新,对术后镇痛提出了更高要求。非甾体抗炎药为我国临床术后镇痛常用的一类药物,近年来应用范围仍在不断扩大,但总结长期术后镇痛用药经验发现,传统的非甾体抗炎药易引起胃肠道毒性反应和血小板抑制,因此迫切需要寻找一种安全、有效的术后镇痛药物。帕瑞昔布钠是一种环氧合酶-2(COX-2)特异性抑制剂,注射使用,可用于术后不同程度疼痛的短期治疗,近年来已被临床实践证实具有良好的疗效和较高的安全性。本文结合已经发表的临床研究报道对该药物在术后镇痛中的应用进展进行综述,旨在对该药物的作用机制、疗效、安全性有一个系统性的认识。

Application of Parecoxib Sodium in Postoperative Analgesia

ABSTRACT: The continuous improvement and innovation of surgical methods put forward higher requirements for postoperative analgesia. Non-steroidal anti-inflammatory drugs are the most commonly used drugs in postoperative analgesia in China, and their application scope is still expanding in recent years. However, according to the experience of long-term postoperative analgesic medication, the traditional non-steroidal anti-inflammatory drugs can cause gastrointestinal toxicity reaction and platelet inhibition, so there''s an urgent need to find a safe and effective postoperative analgesic drugs.Parecoxib sodium injection is a COX-2 (cyclooxygenase-2) specific inhibitor. It can be used for short term treatment of different degrees of pain after operation. In recent years, it has been proved by clinical practice that it has good curative effect and high safety. According to published clinical research reports on the application of the drug in postoperative analgesia, the application of this drug in postoperative analgesia is reviewed in this article. The aim is to provide a systematic understanding of the mechanism, efficacy, and safety of the drug.