丹参注射液与丹参多酚酸盐注射液对不稳定型心绞痛患者冠状动脉微循环的影响

目的:比较丹参注射液与丹参多酚酸盐注射液对不稳定型心绞痛(UA)患者冠状动脉微循环的影响。方法:将2014年5月～2017年5月105例UA患者随机分为丹参组(n=50)与丹参多酚酸盐组(n=55),前者在PCI术前静脉滴注丹参注射液20 mL,1次/d,连续3 d;后者静脉滴注丹参多酚酸盐注射液200 mg,1次/d,连续3 d。分别在PCI术前及术后即刻检测冠状动脉血流储备(CFR)、冠状动脉微循环阻力系数(IMR)及TIMI血流分级。结果:两组术后CFR、IMR及TIMI血流分级均较术前明显改善(P0.05),丹参多酚酸盐组IMR明显小于丹参组(P0.05),CFR、TIMI血流分级与丹参组比较无统计学意义(P0.05)。结论:丹参注射液与丹参多酚酸盐注射液均能显著改善UA患者的冠状动脉微循环,丹参多酚酸盐注射液一定程度上优于丹参注射液。

Effect of Danshen Injection and Salvia Miltiorrhiza Injection on the Coronary Microcirculation in Patients with Unstable Angina Pectoris

ABSTRACT Objective: To compare the effect of Danshen injection and Salvia miltiorrhiza injection on the coronary microcircula- tion in patients with unstable angina pectoris(UA). Methods: 105 cases of patients with UA from May 2014 to May 2017 were randomly divided into the Salvia miltiorrhiza group (n=50) and the Salvia miltiorrhiza polyphenol salt group (n=55), the Salvia miltiorrhiza group was given intravenous drip of Salvia miltiorrhiza injection 20 mL before PCI, 1 time/d, in total 3 d; and the Salvia miltiorrhiza polyphenol salt group was given intravenous drip Salvia miltiorrhiza polyphenol salt injection 200 mg,1 time/d, in total 3 d. The coronary flow re- serve (CFR), coronary microcirculation resistance coefficient (IMR) and TIMI blood flow classification were measured before and imme- diately after PCI. Results: The CFR, IMR and TIMI flow grade of both groups were significantly improved compared with preoperation(P < 0.05), and the IMR of Salvia miltiorrhiza group was significantly lower than that of the Salvianolate group (P<0.05), while the CFR, TIMI flow grade of two groups showed no significant difference(P>0.05). Conclusion: Danshen injection and Salvia miltiorrhiza injection could significantly improve the coronary microcirculation in patients with UA, and the injection of Salvia miltiorrhiza Bunge was better than Danshen injection.