肾康注射液联合前列地尔注射液对慢性肾炎患者肾功能及脂糖代谢的影响

目的:探讨肾康注射液联合前列地尔注射液对慢性肾炎(CN)患者肾功能及脂糖代谢的影响。方法:选取2015年1月至2017年10月海南省中医院收治的CN患者108例为研究对象,按照随机数字表法分为对照组(n=54)和研究组(n=54)。对照组给予前列地尔注射液治疗,研究组在前列地尔注射液的基础上联合肾康注射液治疗,两组均连续治疗12d。比较两组治疗前后肾功能指标、脂糖代谢指标、临床疗效及不良反应发生情况。结果:与治疗前比较,两组治疗后24h尿蛋白定量(24h-UPro)、尿白蛋白排泄率(UAER)、血尿素氮(BUN)、血肌酐(SCr)水平均降低,且研究组低于对照组(P0.05)。与治疗前比较,两组治疗后甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)水平均降低,高密度脂蛋白胆固醇(HDL-C)水平升高,且研究组TG、TC、LDL-C、FBG水平较对照组降低,HDL-C水平较对照组升高(P0.05)。研究组总有效率为92.59%,高于对照组的77.78%,组间比较差异有统计学意义(P0.05)。研究组不良反应发生率为5.56%,与对照组的7.41%比较差异无统计学意义(P0.05)。结论:肾康注射液联合前列地尔注射液治疗CN具有较好的疗效,能有效改善患者肾功能和脂糖代谢,且不会增加不良反应的发生,值得临床推广应用。

Effect of Shen Kang Injection Combined with Alprostadil Injection on Renal Function and Lipid and Glucose Metabolism in Patients with Chronic Nephritis

ABSTRACT Objective: To investigate the effect of Shen Kang injection combined with Alprostadil injection on renal function and lipid and glucose metabolism in patients with chronic nephritis (CN). Methods: A total of 108 patients with CN, who were treated in Traditional Chinese Medicine Hospital of Hainan Province from January 2015 to October 2017, were selected and were randomly divided into control group (n=54) and study group (n=54). The control group was treated with Alprostadil injection, and the study group was treated with Shen Kang injection on the basis of Alprostadil injection. The two groups were treated continuously for 12 days. The indexes of renal function, the indexes of lipid and glucose metabolism, clinical efficacy and adverse reaction before and after treatment were compared between the two groups. Results: Compared with before treatment, the levels of 24h urine protein quantitative (24h-UPro), urinary albumin excretion rate (UAER), blood urea nitrogen (BUN), serum creatinine (SCr) were decreased in the two groups after treatment, and the study group was lower than the control group (P<0.05). Compared with before treatment, the levels of Triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and fasting blood glucose (FBG) in the two groups after treatment were all decreased, and the level of High density lipoprotein cholesterol (HDL-C) was increased, the levels of TG, TC, LDL-C and FBG in the study group were lower than those in the control group, and the level of HDL-C was higher than that in the control group (P<0.05). The total effective rate of the study group was 92.59%, which was higher than that of 77.78% in the control group, and there was a significant difference between the two groups (P<0.05). The incidence of adverse reactions in the study group was 5.56%,and there was no significant difference compared with the 7.41% of the control group (P>0.05). Conclusion: Shen Kang injection combined with Alprostadil injection has a good effect in the treatment of CN. It can effectively improve renal function and lipid and glucose metabolism, and it does not increase the incidence of adverse reactions, which is worthy of clinical application.