Escitalopram oxalate induces apoptosis in U‐87MG cells and autophagy in GBM8401 cells |
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Authors: | Vincent Chin‐Hung Chen Yi‐Hsien Hsieh Li‐Jeng Chen Tsai‐Ching Hsu Bor‐Show Tzang |
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Institution: | 1. Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan;2. Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan;3. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan;4. Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan;5. Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan;6. Immunology Research Center, Chung Shan Medical University, Taichung, Taiwan |
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Abstract: | Glioblastoma multiforme (GBM) is recognized as a most aggressive brain cancer with the worst prognosis and survival time. Owing to the anatomic location of gliomas, surgically removing the tumour is very difficult and avoiding damage to vital brain regions during radiotherapy is impossible. Therefore, therapeutic strategies for malignant glioma must urgently be improved. Recent studies have demonstrated that selective serotonin reuptake inhibitors (SSRIs) have cytotoxic effect on certain cancers. Considering as a more superior SSRI, escitalopram oxalate exhibits favourable tolerability and causes generally mild and temporary adverse events. However, limited information is revealed about the influence of escitalopram oxalate on GBM. Therefore, an attempt was made herein to explore the effects of escitalopram oxalate on GBM. The experimental results revealed that escitalopram oxalate significantly inhibits the proliferation and invasive ability of U‐87MG cells and significantly reduced the expressions of cell cycle inhibitors such as Skp2, P57, P21 and P27. Notably, escitalopram oxalate also induced significant apoptotic cascades in U‐87MG cells and autophagy in GBM8401 cells. An animal study indicated that escitalopram oxalate inhibits the proliferation of xenografted glioblastoma in BALB/c nude mice. These findings implied that escitalopram oxalate may have potential in treatment of glioblastomas. |
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Keywords: | glioblastoma multiforme brain cancer selective serotonin reuptake inhibitor escitalopram oxalate U‐87MG |
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