Fibromodulin reduces scar size and increases scar tensile strength in normal and excessive‐mechanical‐loading porcine cutaneous wounds |
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| Authors: | Soonchul Lee Janette N. Zara Richard Song Chenshuang Li Eric Chen Xinli Zhang Zhihe Zhao Chia Soo Zhong Zheng |
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| Affiliation: | 1. Division of Growth and Development, Section 2. of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA;3. Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University, Gyeonggi‐do, South Korea;4. Department of Bioengineering, School of Engineering, University of California, Los Angeles, Los Angeles, CA, USA;5. State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China;6. UCLA Division of Plastic and Reconstructive Surgery, Department of Orthopaedic Surgery, The Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA, USA |
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| Abstract: | Hypertrophic scarring is a major postoperative complication which leads to severe disfigurement and dysfunction in patients and usually requires multiple surgical revisions due to its high recurrence rates. Excessive‐mechanical‐loading across wounds is an important initiator of hypertrophic scarring formation. In this study, we demonstrate that intradermal administration of a single extracellular matrix (ECM) molecule—fibromodulin (FMOD) protein—can significantly reduce scar size, increase tensile strength, and improve dermal collagen architecture organization in the normal and even excessive‐mechanical‐loading red Duroc pig wound models. Since pig skin is recognized by the Food and Drug Administration as the closest animal equivalent to human skin, and because red Duroc pigs show scarring that closely resembles human proliferative scarring and hypertrophic scarring, FMOD‐based technologies hold high translational potential and applicability to human patients suffering from scarring—especially hypertrophic scarring. |
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| Keywords: | wound healing tissue regeneration scarring hypertrophic scarring fibromodulin |
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