The occurrence of low buoyant density proteoglycans in embryonic chick cartilage |
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Authors: | K Kimata Y Oike K Ito K Karasawa S Suzuki |
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Institution: | Department of Chemistry, Faculty of Science, Nagoya University, Nagoya 464, Japan |
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Abstract: | Two proteoglycan fractions, PCS-H and PCS-L, have previously been isolated from 4 M guanidine HCl extract of embryonic chick cartilages. This communication reports further studies with PCS-L indicating that this fraction contains several different forms, of which one differs from hitherto known cartilage proteoglycans in 1) markedly lower buoyant density, 2) susceptibility to reduction with 2-mercaptoethanol, 3) aggregate-forming ability in 4 M guanidine HCl, and 4) presence of dermatan sulfate-chondroitin sulfate copolymer chains. Also isolated from the PCS-L fraction is a keratan sulfate-rich proteoglycan which represents the smallest molecular size species in cartilage proteoglycan populations. |
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