Effect of cadmium chloride on the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and androgens in the adult male rat |
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Authors: | N H Gopal Dutt K Wakabayashi S Inoue |
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Institution: | 1. Post-graduate Department of Zoology, University of Mysore, Manasagangotri, 570 006, Mysore 2. Institute of Endocrinology, Gunma University, Maebashi, Japan
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Abstract: | Adult male rats injected with cadmium chloride were compared with controls with respect to serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), androgens and testicular histology. A single injection of cadmium chloride (9 mg/kg) was found to bring about no consistent short term changes in the plasma levels of FSH or LH, but after a long period the levels of both these hormones were elevated. In contrast, the levels of androgen showed a sharp increase at 6 h which declined by 12 h. In accordance with the elevated levels of gonadotropins found at 9–28 days after cadmium chloride injection, the androgen levels showed a drastic reduction. Histological aspect of the testis revealed acute necrotic changes of which the vacuolation of spermatid nuclei and fibrosis of Leydig cells are noteworthy. |
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