Structure of the thymus gland, spleen and inguinal lymph nodes of albino rats after immunologic correction during the process of adaptation to physical exercise]

In the experiment performed on 70 noninbred white male rats by means of histological and morphometric techniques construction and cell composition of the thymus, spleen and inguinal lymph nodes have been studied under the influence of systematic physical (swimming) loads. They have been applied under conditions of a pharmacological correction (administration of leacadin) and without it. In the animals not given leacadin, the physical loads result in decrease of the immune function in all the organs investigated. This is evident from decreasing size of the thymus, outgrowth of adipose tissue in it, drop in amount of lymphoid nodules++ in the spleen, decline of contents of lymphocytes in all the organs, and in the cords of the inguinal lymph nodes--decline of plasma cells. Application of leacadin prevents appearance of unfavourable changes.