The comparative cell cycle and metabolic effects of chemical treatments on root tip meristems. III. Chlorsulfuron |
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Authors: | Thomas L Rost |
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Institution: | (1) Department of Botany, University of California, 95616 Davis, California, USA |
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Abstract: | Intact and excised cultured pea roots (Pisum sativum L. cv Alaska) were treated with chlorsulfuron at concentrations ranging from 2.8 ×10–4 M to 2.8×10–6 M. At all concentrations this chemical was demonstrated to inhibit the progression of cells from G2 to mitosis (M) and secondarily from G1 to DNA synthesis (S). The S and M phases were not directly affected, but the transition steps into those phases were inhibited. Total protein synthesis was unaffected by treatment of intact roots with 2.8×10–6 M chlorsulfuron. RNA synthesis was inhibited by 43% over a 24-h treatment period. It is hypothesized that chlorsulfuron inhibits cell cycle progression by blocking the G2 and G1 transition points through inhibition of cell cycle specific RNA synthesis. |
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