Allelopathic actions of the alkaloid 12-epi-hapalindole E isonitrile and calothrixin A from cyanobacteria of the genera Fischerella and Calothrix |
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| Authors: | Nga Thanh Doan Rodney W. Rickards Jennifer M. Rothschild Geoffrey D. Smith |
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| Affiliation: | (1) Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, Australia;(2) Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Australia;(3) Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, ACT, 0200, Australia |
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| Abstract: | The alkaloids 12-epi-hapalindole E isonitrile,isolated from the cyanobacterium Fischerellasp., and the indolophenanthridine calothrixin A, fromCalothrix sp., were characterized in terms oftheir ability to kill several organisms and celltypes, and their biochemical modes of action. Bothcompounds inhibited RNA synthesis, and consequentlyprotein synthesis, in Bacillus subtilis. Calothrixin A also inhibited DNA replication, thehapalindole having little effect on this process. Measurements of in vitro RNA synthesis confirmedthe in vivo results and suggested that bothcompounds inhibit RNA polymerase directly; the degreeof inhibition was independent of the DNAconcentration, but strongly dependent on thepolymerase concentration. |
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| Keywords: | cyanobacteria bioactive compounds allelopathy calothrixin hapalindole alkaloids Fischerella Calothrix |
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