Synthesis, radiolabelling and biological characterization of (D)-7-iodo-N-(1-phosphonoethyl)-5-aminomethylquinoxaline-2,3-dione, a glycine-binding site antagonist of NMDA receptors |
| |
Authors: | Ametamey S M Kokic M Carrey-Rémy N Bläuenstein P Willmann M Bischoff S Schmutz M Schubiger P A Auberson Y P |
| |
Affiliation: | Center for Radiopharmaceutical Science of the ETH, Paul Scherrer Institute and Division of Nuclear Medicine, University Hospital Zurich, Villigen PSI, Switzerland. simon-mensah.ametamey@psi.ch |
| |
Abstract: | (D)-7-Iodo-N-(1-phosphonoethyl)-5-aminomethylquinoxaline-2,3 -dione (I-PAMQX), is a potent, in vivo active antagonist acting at the glycine binding site of the NMDA receptor complex. Radioiodinated [131I]I-PAMQX was prepared with good yields and high specific activity from its 7-bromo analogue. Biodistribution studies of [131I]I-PAMQX in mice showed a relatively slow clearance from the blood. The uptake of radioactivity was highest in the kidneys, moderate in the heart, lung, liver and bones, and low in the brain. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|