Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli |
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Authors: | Kevin T Watts Pyung C Lee Claudia Schmidt-Dannert |
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Institution: | (1) Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St. Paul, MN 55108, USA |
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Abstract: | Background Phenylpropanoids are the precursors to a range of important plant metabolites such as the cell wall constituent lignin and
the secondary metabolites belonging to the flavonoid/stilbene class of compounds. The latter class of plant natural products
has been shown to function in a wide range of biological activities. During the last few years an increasing number of health
benefits have been associated with these compounds. In particular, they demonstrate potent antioxidant activity and the ability
to selectively inhibit certain tyrosine kinases. Biosynthesis of many medicinally important plant secondary metabolites, including
stilbenes, is frequently not very well understood and under tight spatial and temporal control, limiting their availability
from plant sources. As an alternative, we sought to develop an approach for the biosynthesis of diverse stilbenes by engineered
recombinant microbial cells. |
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