The core structure of the lipopolysaccharide from the causative agent of plague, Yersinia pestis |
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| Authors: | Vinogradov Evgeny V Lindner Buko Kocharova Nina A Senchenkova Sof'ya N Shashkov Aleksander S Knirel Yuriy A Holst Otto Gremyakova Tat'yana A Shaikhutdinova Rima Z Anisimov Andrei P |
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| Affiliation: | N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospekt 47,Moscow 119991, Russia. |
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| Abstract: | The rough-type lipopolysaccharide (LPS) of the plague pathogen, Yersinia pestis, was studied after mild-acid and strong-alkaline degradations by chemical analyses, NMR spectroscopy and electrospray-ionization mass spectrometry, and the following structure of the core region was determined:where L-alpha-D-Hep stands for L-glycero-alpha-D-manno-heptose, Sug1 for either 3-deoxy-alpha-D-manno-oct-2-ulosonic acid (alpha-Kdo) or D-glycero-alpha-D-talo-oct-2-ulosonic acid (alpha-Ko), and Sug2 for either beta-D-galactose or D-glycero-alpha-D-manno-heptose. A minority of the LPS molecules lacks GlcNAc. |
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| Keywords: | Lipopolysaccharide Yersinia pestis Core structure |
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