Comparative mapping of human Chromosome 2 identifies segments of conserved synteny near the bovine mh locus |
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| Authors: | Tad S. Sonstegard Nestor L. Lopez-Corrales Steven M. Kappes Craig W. Beattie Timothy P.L. Smith |
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| Affiliation: | (1) U.S. Department of Agriculture, Agricultural Research Service, U.S. Meat Animal Research Center (MARC), P.O. Box 166, Spur 18D, Clay Center, Nebraska 68933-0166, USA, US |
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| Abstract: | The ``double-muscling' (mh) locus has been localized to an interval between the centromere and the microsatellite marker TGLA44 on bovine Chromosome (Chr) 2 (BTA2). We identified segments of conserved synteny that correspond to this region of BTA2 by assigning large genomic clones containing bovine homologs of seven genes from the long arm of human Chr 2 (HSA2q). Polymorphic markers developed from these clones integrated the physical and linkage maps of BTA2 from 2q12 to 2q44 and extended genetic coverage towards the centromere. This comparative analysis suggests the mh locus resides on HSA2q near both the protein C and collagen type III alpha-1 genes. Overall, our data reveal a complex rearrangement of gene order between BTA2q12-44 and HSA2q14-37 that underscores the need to establish boundaries of conserved synteny when applying comparative mapping information to identify genes or traits of interest. Received: 3 March 1997 / Accepted: 12 May 1997 |
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