Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives |
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| Authors: | Balaydın Halis T Sentürk Murat Menzek Abdullah |
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| Institution: | 1. Artvin Çoruh University, Education Faculty, 08000 Artvin, Turkey;2. Atatürk University, Department of Chemistry, 25240 Erzurum, Turkey;3. Agri Ibrahim Cecen University, Department of Chemistry, 04100 Agri, Turkey |
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| Abstract: | The Naturally occurring novel cyclohexanonyl bromophenol 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)cyclohexanone (4) was synthesized as a racemic compound. Cyclohexylphenyl methane derivatives (10-17) with Br, OMe, CO, and OH were also obtained. Inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II, IV, and VI, with compounds 2-4, 8, and 10-26 was investigated. These compounds were found to be promising carbonic anhydrase inhibitors and some of them showed interesting inhibitory activity. Some of the compounds investigated here showed effective hCA inhibitory activity, and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, and osteoporosis. |
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