Piecewise exponential survival curves with smooth transitions |
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Authors: | Daniel Zelterman Patricia M Grambsch Chap T Le Jennie Z Ma James W Curtsinger |
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Abstract: | Several models of a population survival curve composed of two piecewise exponential distributions are developed. In one formulation the hazard rate changes at a point that is an unobservable random variable that varies between individuals. The population hazard function may decrease with age even when all individuals' hazards are increasing. In a second formulation, the population hazard function is modeled directly. Several models are fit to the survival history of a cohort of 5751 highly inbred male Drosophila melanogaster and the British coal mining disaster data. |
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