|
|||||
|
|
Uptake and degradation of bovine testes beta-galactosidase by parenchymal and nonparenchymal rat liver cells |
|
| Authors: | R Blomhoff H K Blomhoff H Tolleshaug T B Christensen T Berg |
| Abstract: | The plasma half-life of beta-galactosidase in rat was about 1.5 min. Ten minutes after in vivo injection, 45% of the enzyme was recovered in liver, with hepatocytes and endothelial cells as the predominant cell types responsible for uptake. In vitro uptake of beta-galactosidase in hepatocytes and nonparenchymal liver cells was saturable, Ca2+-dependent and it could be partly inhibited by mannose or alpha-methyl-mannoside. |
| Keywords: | |