Comparative Genomic Analysis of Genes Encoding Translation Elongation Factor 1Bα in Human and Mouse Shows EEF1B1 to Be a Recent Retrotransposition Event |
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| Authors: | Doreen M. Chambers Guy A. Rouleau Catherine M. Abbott |
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| Affiliation: | a Medical Genetics Section, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK;b Centre for Research in Neuroscience, McGill University, Montreal General Hospital Research, Institute, Quebec, [POSTAL CODE?], Canada |
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| Abstract: | We have characterized genomic loci encoding translation elongation factor 1Bα (eEF1Bα) in mice and humans. Mice have a single structural locus (named Eef1b2) spanning six exons, which is ubiquitously expressed and maps close to Casp8 on mouse chromosome 1, and a processed pseudogene. Humans have a single intron-containing locus, EEF1B2, which maps to 2q33, and an intronless paralogue expressed only in brain and muscle (EEF1B3). Another locus described previously, EEF1B1, is actually a processed pseudogene on chromosome 15 corresponding to an alternative splice form of EEF1B2. Our study illustrates the value of comparative mapping in distinguishing between processed pseudogenes and intronless paralogues. |
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| Keywords: | Abbreviations: translationAbbreviations: elongationAbbreviations: EEF1BAbbreviations: Eef1bAbbreviations: pseudogeneAbbreviations: paralogueAbbreviations: gene mappingAbbreviations: amyotrophic lateral sclerosisAbbreviations: ALS2 |
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