Sulfenamides as prodrugs of NH-acidic compounds: a new prodrug option for the amide bond |
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Authors: | Guarino Victor R Karunaratne Veranja Stella Valentino J |
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Institution: | Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA. |
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Abstract: | The objective of this report is to introduce the novel concept of utilizing sulfenamides as prodrugs for compounds containing an NH-acidic functionality, particularly weakly acidic amide-type functionalities (amides, ureas, carbamates, etc.). Included are the syntheses and physicochemical characterizations of some model sulfenamides to illustrate the promise of this new prodrug technology. |
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