Stable and orally bio-available pro-drugs of CPS11 |
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| Authors: | Huo Aihong Zhang Hesheng Guan Yongbiao Zeng Guanghuai Chen Yingwei Li Xingwen |
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| Affiliation: | Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. |
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| Abstract: | Stable and orally bio-available pro-drugs of CPS11 were synthesized. They are active on human umbilical vein endothelial cell proliferation assay and tube formation assay. The therapeutic efficacy and safety of 4 as a single agent or combined with Taxol in the treatment of MX-1 human breast cancer xenograft were evaluated. Compound 4 as a single agent failed to produce an anti-tumor activity, while it significantly enhanced antitumor potency of Taxol. |
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| Keywords: | CPS11 Pro-drug Anti-cancer Synergist |
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