C-terminal amidation of acylamino acids and peptides using a transpeptidation method catalyzed by carboxypeptidase Y

The carboxypeptidase Y-catalyzed reaction of acyl transfer of acylamino acid and peptide residues from the corresponding esters to ammonia and to amides of amino acids has been studied, and conditions for obtaining amides of amino acids and peptides with the yields up to 90% found.