Somato-dendritic synapses in the nucleus reticularis thalami of the rat |
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Authors: | Csillik B Pálfi A Gulya K Mihály A Knyihár-Csillik Elizabeth |
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Affiliation: | Department of Anatomy, Albert Szent-Gy?rgyi Medical and Pharmaceutical Center, University of Szeged, Hungary. csillik@anat-fm.szote.u-szeged.hu |
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Abstract: | In the reticular nucleus of the rat thalamus, about 30% of the synapses are brought about by the perikarya of parvalbumin-immunopositive neurons, which establish somato-dendritic synapses with large dendrites of nerve cells of specific thalamic nuclei. Although the parvalbumin-immunopositive presynaptic structures bear resemblance to goblet-like or calyciform axonal endings, electron microscopic immunocytochemistry and in situ hybridization revealed that these structures are parts of the perikaryal cytoplasm studded with synaptic vesicles. In about 15% of the somato-dendritic synapses, axons are seen to be in synaptic contact with the parvalbumin-immunoreactive perikaryon. Double immunohistochemical staining revealed that the parvalbumin immunoreactive presynaptic perikarya and dendrites contained GABA. It is assumed that the peculiar somato-dendritic synaptic complexes subserve the goal of filtration of impulses arriving at the reticular nucleus from various thalamic nuclei, thus processing them for further sampling. |
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