Role of transition metals present in air particulate matter on lung oxygen metabolism |
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| Affiliation: | 1. Universidad de Buenos Aires, CONICET, Instituto de Bioquímica Medicina Molecular (IBIMOL), Cátedra de Química General e Inorgánica, Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina;2. Universidad de Buenos Aires, CONICET, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Càtedra de Química Analítica Instrumental, Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina;1. Department of Physics, Manonmaniam Sundaranar University, Tirunelveli, 627012, Tamilnadu, India;2. CISL, Department of Physics, Annamalai University, Annamalai Nagar, 608002, Tamilnadu, India;1. Institut National de Recherche et de Sécurité pour la prévention des accidents de travail et des maladies professionnelles (INRS) : 1, rue du Morvan, CS 60027, 54519Vandœuvre-lès-Nancy Cedex, France;2. Université de Lille, EA 4483 : 1, place de Verdun, 59045 Lille, France;3. Centre Hospitalier Universitaire de Lille, Service des Explorations Fonctionnelles Respiratoires : 2, avenue Oscar Lambret, 59037 Lille Cedex, France;4. Centre Hospitalier Universitaire de Lille, Service de Médecine du Travail du Personnel Hospitalier : 2, avenue Oscar Lambret, 59037 Lille Cedex, France;1. Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan;2. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;3. Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;4. School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan;5. School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan;6. Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan;1. Institute of Cardiovascular Physiopathology, Department of Pathology, Faculty of Medicine, University of Buenos Aires, Argentina;2. Institute of Biochemistry and Molecular Medicine (IBIMOL UBA-CONICET), Faculty of Medicine, Argentina;3. Institute of Biochemistry and Molecular Medicine (IBIMOL UBA-CONICET), School of Pharmacy and Biochemistry; University of Buenos Aires, Buenos Aires, Argentina;1. Departamento de Mineralogía y Petrología, Facultad de Ciencia y Tecnología, Universidad del País Vasco (UPV/EHU), Apdo 644, 48080 Bilbao, Spain;2. BCMaterials Parque Tecnológico de Zamudio, Ibaizabal Bidea, Edificio 500–Planta 1, 48160 Derio, Spain;3. Departamento de Química Inorgánica, Facultad de Ciencia y Tecnología, Universidad del País Vasco (UPV/EHU), Apdo 644, 48080 Bilbao, Spain;4. QUIMOLMAT, Centro de Investigaciones Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Facultad de Ciencias, Universidad de A Coruña, 15071A Coruña, Spain |
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| Abstract: | Several epidemiological studies have shown a positive correlation between daily increases in airborne particulate matter (PM) concentration and the occurrence of respiratory and cardiovascular diseases. Transition metals present in air PM were associated with adverse health effects after PM exposure. The aim of this work was to study lung O2 metabolism after an acute exposure to transition metal-coated nanoparticles (NPs). Female Swiss mice (25 g) were intranasally instilled with a suspension of silica NP containing Ni (II), Cd (II), Fe (III), or Cr (VI) at 0, 0.01, 0.05, 0.1, and 1.0 mg metal/kg body weight. Lung O2 consumption was found to be significantly increased after the exposure to most doses of Ni-NP and Fe-NP, and the 0.05 mg metal/kg body weight dose of Cr-NP, while no changes were observed for Cd-NP. Lucigenin chemiluminescence (as an indicator of NADPH oxidase (NOX) activity) was evaluated in lung homogenates. Only Ni-NP and Fe-NP have shown the ability to induce a significant increase in lucigenin chemiluminescence. In order to establish the possible occurrence of pulmonary oxidative stress, TBARS levels and the GSH/GSSG ratio were determined. The higher doses of Ni-NP and Fe-NP were able to induce an oxidative stress condition, as shown by changes in both TBARS levels and the GSH/GSSG ratio. Taken together, the present results show differential effects for all the metals tested. These findings emphasize the importance of transition metals present air PM in PM adverse health effects, and contribute to the understanding of the pathological mechanisms triggered by the exposure to environmental PM. |
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| Keywords: | Air pollution Lung Transition metals NADPH oxidase |
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