A panoramic review and in silico analysis of IL-11 structure and function |
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| Affiliation: | 1. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;2. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran;3. Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran;1. College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 660-701, Republic of Korea;2. Environmental Health Research Department, Environmental Research Complex, Incheon 404-708, Republic of Korea;3. Animal Biosciences and Biotechnology Laboratory, BARC, ARS, USDA, Beltsville, MD 20705, USA;4. Department of Animal Science, College of Agriculture, Gyeongsang National University, Jinju 660-701, Republic of Korea;1. Department of Medical Microbiology, Indian Council of Medical Research, Regional Medical Research Centre, Post Bag No-13, Port Blair, Andaman and Nicobar Islands, 744101, India;2. Department of Veterinary Microbiology, West-Bengal University of Animal and Fishery Sciences, West Bengal, 700037, India;1. Institute of Biochemistry, Kiel University, 24098 Kiel, Germany;2. Medical Faculty, Institute of Biochemistry and Molecular Biology II, Heinrich-Heine-University, 40225 Düsseldorf, Germany;3. Institute of Biochemistry and Molecular Biology, RWTH Aachen, 52074 Aachen, Germany;4. CONARIS Research Institute AG, 24118 Kiel, Germany;1. Division of Fisheries Biotechnology & Molecular Biology, Department of Biotechnology, Faculty of Science and Humanities, SRM University, Kattankulathur, 603 203 Chennai, Tamil Nadu, India;2. Department of Biotechnology, SRM Arts & Science College, Kattankulathur, Chennai 603 203, India;3. SRM Research Institute, SRM University, Kattankulathur, 603 203 Chennai, Tamil Nadu, India;4. Addiriyah Research Chair for Environmental Studies, Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia |
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| Abstract: | Human Interleukin (IL)-11 is a multifunctional cytokine, recognized for its thrombopoietic effects for more than two decades; clinically, IL-11 is used in the treatment of thrombocytopenia. IL-11 shares structural and functional similarities with IL-6, a related family member. In recent years, there has been a renewed interest in IL-11, because its distinct biological activities associated with cancers of epithelial origin and inflammatory disorders have been revealed. Although the crystal structure of IL-11 was resolved more than two years, a better understanding of the mechanisms of IL-11 action is required to further extend the clinical use of IL-11. This review will discuss the available structural, functional, and bioinformatics knowledge concerning IL-11 and will summarize its relationship with several diseases. |
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| Keywords: | Interleukin-11 Cytokine Interleukin-6 Cancer Inflammation GP-130 |
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