S100A7: A rAMPing up AMP molecule in psoriasis |
| |
| Affiliation: | 1. Department of Oral Pathology, Ziauddin College of Dentistry, Ziauddin University, 75600 Karachi, Pakistan;2. Department of Pathology, Ziauddin Medical College, Ziauddin University, 75600 Karachi, Pakistan;3. Faculty of Dentistry, Ziauddin University, Karachi, Pakistan;4. Department of Oral Biology, Ziauddin College of Dentistry, Ziauddin University, 75600 Karachi, Pakistan;5. Department of Periodontology, Ziauddin College of Dentistry, Ziauddin University, 75600 Karachi, Pakistan |
| |
| Abstract: | S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests that S100A7 plays critical roles in amplifying the inflammatory process in psoriatic skin, perpetuating the disease phenotype. This review will discuss the interactions between S100A7 and cytokines in psoriatic skin. Furthermore, we will focus our discussion on regulation and functions of S100A7 in psoriasis. Finally, we will discuss the possible use of S100A7 as therapeutic target in psoriasis. |
| |
| Keywords: | S100A7 Psoriasin Keratinocyte Psoriasis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
