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Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines
Affiliation:1. Thoracic Oncology Research Group, School of Clinical Medicine, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, St James''s Hospital & Trinity College Dublin, Ireland;2. Flow Cytometry Facility, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, Ireland;3. Medical Oncology Department, St James''s Hospital, Dublin, Ireland;4. Histopathology Department, St James''s Hospital & Trinity College Dublin, Ireland;5. Cancer & Ageing Research Program, Queensland University of Technology, Brisbane, Australia
Abstract:
Keywords:Aldehyde dehydrogenase 1A1  Drug resistance  Ovarian cancer stem cells  Anticancer therapy  Drug transporters
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