Morphometrical studies of erythrophagocytosis in the spleen |
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| Authors: | N Zimmermann G Schloeffel J Unger K J Halbhuber L Paetzold W Linss |
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| Institution: | Institude of Anatomy, Friedrich-Schiller University, Jena, GDR. |
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| Abstract: | The elimination of altered RBC was investigated morphometrically in the rat spleen by determination of the percentage of erythrophagosomes in macrophages. PHZ and diamide treated RBC led to a time dependent increase of the percentage of erythrophagosomes in comparison to normal spleens. The deformability of the target RBC was lowered as revealed by measurements with glass micropipettes. RBC-microvesicles and diamide treated RBC are primarily loaded with IgG and undergo a rapid elimination. PHZ-RBC and cells with a prolonged stay in the spleen are sequestrated by secondary mechanisms. Details of primary and secondary elimination are discussed. |
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