Lipase-catalyzed esterification in organic solvent to resolve racemic naproxen |
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| Authors: | Y.-m. Cui D.-z. Wei J.-t. Yu |
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| Affiliation: | (1) Research Institute of Biochemistry, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China |
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| Abstract: | Lipase from Candida cylindracea was used to catalyze the enantioselective esterification in isooctane to resolve naproxen. The conversion was 33.5% over 11 days. The enantiomer excess of product (ee %) was about 100% at this conversion when octanol acted as the other substrate. |
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