Role of B cells in maintaining helper T-cell memory |
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Authors: | van Essen D Dullforce P Gray D |
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Affiliation: | Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK. |
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Abstract: | The cellular interactions involved in maintaining CD4+ T-cell memory have hitherto not been identified. In this report, we have investigated the role played by B cells in this process. We show that that long-lasting helper T-cell memory depends on the presence of B cells, but that direct antigen presentation by B cells is not required. These findings provide new insights into the mechanisms which underlie helper T-cell memory. They also suggest that the efficacy of future vaccines will depend critically on the inclusion of B- as well as T-cell epitopes. |
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