The human V pre B gene is located on chromosome 22 near a cluster of {\text{V}}_{\lambda _1 } gene segments期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The human V pre B gene is located on chromosome 22 near a cluster of {\text{V}}_{\lambda _1 } gene segments

Authors:	Steven R Bauer Kay Huebner Marcia Budarf Janet Finan Jan Erikson Beverly S Emanuel Peter C Nowell Carlo M Croce Fritz Melchers

Institution:	(1) Basel Institute for Immunology, Basel, Switzerland;(2) Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, 19104 Philadelphia, PA, USA;(3) Department of Pediatrics, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, 19104 Philadelphia, PA, USA;(4) Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104 Philadelphia, PA, USA;(5) Institute for Cancer Research, 19111 Philadelphia, PA, USA

Abstract:	The chromosomal location of the human V _pre B gene was determined by Southern blotting analysis of restriction enzyme-digested DNAs from a panel of 17 mouse-human somatic cell hybrids. The pattern of hybridization of a V_preB-specific probe in conjunction with earlier analysis of several marker genes allowed the following conclusions: 1) V _pre B is on human chromosome 22 within band 22q11.2 distal to the bcr-like gene, bcr-2 and proximal to the bcr-like gene, bcr-4. 2) V_preB has been localized relative to several constitutional and tumor-specific breakpoints within 22q 11.2, segregates in hybrids retaining 22q^–chromosomes with some but not with all members of the ${\text{V}}_{\lambda _1 }$ subgroup of the V genes, and is amplified with these genes in K562 cells. 3) The order of the loci on chromosome 22 is centromerebcr-2, V _preB, ${\text{V}}_{\lambda _1 } \to bcr - 4 \to C_\lambda \to bcr - 1 \to bcr - 3 \to sis$ .

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