Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi |
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| Authors: | Ribeiro Tatiana Santana Freire-de-Lima Leonardo Previato José Osvaldo Mendonça-Previato Lucia Heise Norton de Lima Marco Edilson Freire |
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| Affiliation: | Universidade Federal Rural do Rio de Janeiro, Instituto de Ciências Exatas, Departamento de Química, Km 7, BR 465 CEP: 23.890-000, Seropédica, RJ Brazil. |
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| Abstract: | We describe herein an evaluation of trypanocidal effects of the natural alkaloid piperine and twelve synthetic derivatives against epimastigote and amastigote forms of the protozoan parasite Trypanosoma cruzi, the causative agent of the incurable human disease, Chagas' disease. The results obtained point to piperine as a suitable template for the development of new drugs with trypanocidal activity. |
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