Variations of brain histamine levels in germ-free and nephrectomized rats |
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| Authors: | Dr Linda R Hegstrand Dr R Jean Hine |
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| Institution: | (1) The Waisman Center on Mental Retardation and Human Development, Wisconsin Psychiatric Research Institute, Madison, Wisconsin;(2) William S. Middleton Memorial Veterans Hospital, Madison, Wisconnin;(3) Neurochemistry Section, 765 Waisman Center, 1500 Highland Avenue, 53705 Madison, WI;(4) Present address: Department of International Health Sciences, School of Public Health, University of Alabama, 35294 Birmingham, Alabama |
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| Abstract: | The influence of nephrectomy on brain and peripheral tissue histamine and on brain norepinephrine, dopamine, serotonin, and 5-hydroxyindoleacetic acid was studied in germ-free and conventionally housed rats. The conventional controls had higher levels of histamine in the hypothalamus than the germ-free control animals, but no differences existed for histamine in whole brain minus the hypothalamus or in peripheral tissues. Nephrectomy increased brain histamine and 5-hydroxyindoleacetic acid levels in both germ-free and conventional rats, but had no effect on norepinephrine, dopamine or serotonin. In contrast, the histamine level in the heart of the nephrectomized germ-free animals was lower than that for germ-free controls. There were no changes in the heart or liver histamine levels of the conventional nephrectomized rats. |
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