Rat Brain 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Subcellular Distribution and Cold Lability |
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| Authors: | Tarun B Patel John B Clark |
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| Institution: | Department of Biochemistry, St. Bartholomew's Hospital Medical College, University of London, Charterhouse Square, London EC1M 6BQ, U.K. |
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| Abstract: | Abstract: Data are provided indicating that the rat brain 3-hydroxy-3-methyl-glutaryl-CoA reductase is similar to the enzyme from other tissues as far as diurnal rythmicity, cold lability and half-life measurements at 0°C are concerned. The enzyme activity in the brain decreased with age of the animals. Subcellular fractionation studies demonstrate that while 77% of the activity was associated with the microsomal fraction, 19% of the enzyme activity was recovered in the mitochondrial fraction. The possible function of such a mitochondrially located 3-hydroxy-3-methylglutaryl-CoA reductase in rat brain is discussed. |
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| Keywords: | 3-Hydroxy-3-methylglutaryl-CoA reductase Distribution subcellular Lability cold |
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