Bone loss: Therapeutic approaches for preventing bone loss in inflammatory arthritis |
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Authors: | Qaiser Rehman Nancy E Lane |
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Affiliation: | (1) University of California, San Francisco, CA, USA; |
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Abstract: | Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. Recent studies have highlighted the importance of receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast activation by inflammatory cells and subsequent bone loss. In this article, we review the pathogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it. |
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