Efficient synthesis of rhodamine conjugates through the 2'-position |
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Authors: | Adamczyk M Grote J |
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Affiliation: | Department of Organic Chemistry, Abbott Laboratories, Abbott Park, IL 60064-6016, USA. maciej.adamczyk@abbott.com |
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Abstract: | Reaction of substrates containing primary amines with rhodamine 2'-esters cleanly produces fluorescent rhodamine 2'-amide conjugates at ambient temperature. Only primary amines react with the esters under these conditions. Chemoselectivity can thus be achieved in substrates containing different types of amines. |
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