Role of nicotinic acid as modulator of liposomal microviscosity |
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| Authors: | M. Chatterjee R. Basu P. Nandy |
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| Affiliation: | (1) Department of Physics, Jadavpur University, 700 032 Calcutta, India;(2) Present address: Guha Institute of Biochemistry, 55/5 Purna Das Road, 700 029 Calcutta, India |
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| Abstract: | Using the fluorescent probe 1,6-diphenyl-1,3,5 hexatriene, we have investigated the effect of nicotinic acid, a derivative of the toxic alkaloid nicotine, on the fluidity profile and activation energy of diffusion in the liposomal system of several lipids. We have also studied how the fluidizing property of nicotinic acid affects the intermediate fluid condition induced by cholesterol in these liposomal systems |
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| Keywords: | Nicotinic acid phospholipid fluidity phase transition |
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